Henry was a character in The Last of Us. He appeared as a survivor from Hartford and the older brother of Sam, who he was fiercely protective of, to the point of underestimating his comprehension and capability in hostile situations. He openly chastised Sam if he believed he did something that would compromise their efficiency or, in particular, his safety.

He was voiced by Brandon Scott. Henry and his brother were among survivors who had left Hartford, after the military abandoned the quarantine zone. On the suggestion of someone within their group, they entered Pittsburgh to search for supplies and were subsequently ambushed by the Hunters within the city. Before they become separated, the group agreed to meet up near a radio tower just outside of the city limits.

For the next few days, Henry and Sam holed up in an office building near one the Hunters' lookouts. Henry and Sam were hiding out in an apartment building when they encountered Ellie and Joel. Assuming Joel was a Hunter, Henry attacked him, gaining a momentary upper hand before Ellie slashed him with her switchblade. Distracted, he was unable to defend against Joel’s counter and was thrown to the ground where Joel proceeded to punch him in the kidneys and the back of his neck. Ellie warned her partner about his younger brother, who had a gun trained on him. Henry assured his brother that they are not “the bad guys” and Joel backed off, allowing Henry to recover.

Winded, Henry complimented his strength. Joel bluntly stated that it was his intention to kill Henry in their altercation. The two introduced themselves and explained their situation. Henry suggested that they could help each other get out of the city, and though Joel initially rejected the idea, Ellie’s compliance changed his mind. Henry and Sam lead the two out of the apartment to their hideout; they took cover inside a toy store when the armored vehicle patrolling the street reappeared.

Though Henry was frustrated at the Hunter’s persistence, he noticed Sam fiddling with a toy. He reminded his brother that they take only what they need and lead them back to an office building where they had been staying. Once inside, Joel questioned how Henry planned to escape the city, asking why they have not yet left. Henry replied that they were waiting for the right opportunity. He lead Joel to a window overlooking the gate guarded by multiple Hunters. He explained that he and Sam planned on escaping through the gate once the primary detail was replaced by a skeleton crew at night.

Henry told Joel they were heading West to join the Fireflies. He became defensive when Joel asked why he was "dragging" his brother across the country on the possibility of finding the Fireflies. Joel defused Henry by revealing that he too and Ellie were also searching for the rebel group.

At ease, Henry explained to Joel his group planned to meet at the military radio tower just outside the city the following day. By nightfall, the four of them make their way to the lower level of the office building. Henry and Joel killed the first two men in the skeleton crew and while avoiding the spotlight searching for Clickers, they proceeded outside. Joel created a distraction by turning off the generator, drawing the men atop the bridge down onto the ground.

Henry, Joel and Ellie killed the group but not without drawing attention. They managed to pass through the doors and lock them but they were given no reprieve. Acting quickly, Henry and Sam scaled a ladder onto the top of a truck blocking their exit. However, no sooner had Henry lifted Ellie up onto the truck, the ladder broke, stopping Joel from reaching them. The Hunters rammed through the barricade doors with their Humvee. Prioritizing his brother's safety, Henry left Joel; Sam was shocked by his brother's actions but followed him.

The two made it somewhere past the bridge where they spotted Ellie and Joel drifting through the water. They saved them and waited for Joel to regain consciousness. When Joel awoke, he attacked Henry for leaving them and threatened to kill him. Henry remained calm and reminded Joel that his brother’s safety came first; he would have done the same to Henry if their situations were reversed.

After Joel calmed down, Henry assured Sam he was alright and the two began searching for a way off the beach. They come across a large storm drain which the group entered into an underground sewer system. While traveling through the sewers, they discovered a group of deceased survivors had attempted to make a living in the sewers but were inevitably overtaken by the cordyceps brain infection. Henry and the others initially evaded detection from the infected roaming the sewers — however, Joel triggered a jerry-rigged door that slammed shut and separated the group.